Skip to content
New issue

Have a question about this project? Sign up for a free GitHub account to open an issue and contact its maintainers and the community.

By clicking “Sign up for GitHub”, you agree to our terms of service and privacy statement. We’ll occasionally send you account related emails.

Already on GitHub? Sign in to your account

System creates ambiguous RNA nucleotides instead of DNA ones in case of DNA antisense stand creation #6609

Open
AlexeyGirin opened this issue Mar 5, 2025 · 0 comments
Labels
Antisense Bucket: Antisense related issues Priority: High Sequence mode Bucket: Sequence mode related issues Severity: High High level visibility to the user

Comments

@AlexeyGirin
Copy link
Collaborator

AlexeyGirin commented Mar 5, 2025

Steps to Reproduce

  1. Go to Macro - Sequence mode (clean canvas)
  2. Load canvas with:
  1. Select all nucleotides and call context menu
    Image
  2. Click Create DNA antisense stand option

Actual behavior
System creates ambiguous RNA nucleotides (with Uracil) instead of DNA ones (with Thymine)
Image

Expected behavior
System creates ambiguous DNA nucleotides (with Uracil) instead of DNA ones (with Thymine)
Image

As per requirements:

Details

1.2. Every "antisense base" should be created following the table bellow:

Sense base Antisense base
N (ambiguous DNA base) and N (ambiguous RNA base) N (ambiguous DNA base)
D (ambiguous DNA base) and D (ambiguous RNA base) H (ambiguous DNA base)
H (ambiguous DNA base) and H (ambiguous RNA base) D (ambiguous DNA base)
W (ambiguous DNA base) and W (ambiguous RNA base) W (ambiguous DNA base)
M (ambiguous base) K (ambiguous DNA base)
R (ambiguous base) Y (ambiguous DNA base)
V (ambiguous base) B (ambiguous DNA base)

Versions

  • Ketcher Version 3.2.0-rc.1 Build at 2025-03-04; 14:24:35
  • Indigo Version 1.30.0-rc.1.0-g9bdedaba9-wasm32-wasm-clang-19.0.0
  • Chrome Version 134.0.6998.36 (Official Build) (64-bit)
  • Win10

Issue found while testing: #6383

@AlexeyGirin AlexeyGirin added Antisense Bucket: Antisense related issues Priority: High Sequence mode Bucket: Sequence mode related issues Severity: High High level visibility to the user labels Mar 5, 2025
@AlexeyGirin AlexeyGirin added this to the Ketcher 3.2.0-rc.2 milestone Mar 5, 2025
Sign up for free to join this conversation on GitHub. Already have an account? Sign in to comment
Labels
Antisense Bucket: Antisense related issues Priority: High Sequence mode Bucket: Sequence mode related issues Severity: High High level visibility to the user
Projects
None yet
Development

No branches or pull requests

1 participant