diff --git a/.github/workflows/cmake.yml b/.github/workflows/cmake.yml
index 2e9d67be5c222..b425fc4ea1e64 100644
--- a/.github/workflows/cmake.yml
+++ b/.github/workflows/cmake.yml
@@ -227,7 +227,7 @@ jobs:
 
       - name: Generate build system
         run: |
-          cmake -B build -DCMAKE_C_COMPILER=gcc-11 -DCMAKE_CXX_COMPILER=g++-11 -DBoost_INCLUDE_DIR="${PWD}/${{ matrix.conf.boost_archive }}" -DENABLE_WALLET=ON -DWITH_EXTERNAL_SIGNER=ON -DWITH_MINIUPNPC=ON -DWITH_NATPMP=ON -DWITH_ZMQ=ON -DWITH_USDT=ON -DWERROR=ON
+          cmake -B build --preset ci-linux -DCMAKE_C_COMPILER=gcc-11 -DCMAKE_CXX_COMPILER=g++-11 -DBoost_INCLUDE_DIR="${PWD}/${{ matrix.conf.boost_archive }}"
 
       - name: Build
         working-directory: build
@@ -576,7 +576,7 @@ jobs:
 
       - name: Generate build system
         run: |
-          ${{ matrix.xcode.configure_env }} cmake -B build -DWERROR=ON
+          ${{ matrix.xcode.configure_env }} cmake -B build --preset ci-darwin
 
       - name: Build
         env:
diff --git a/CMakeLists.txt b/CMakeLists.txt
index bc8dccaea9b47..824cbfea14144 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -70,9 +70,32 @@ option(REDUCE_EXPORTS "Attempt to reduce exported symbols in the resulting execu
 option(WERROR "Treat compiler warnings as errors." OFF)
 
 tristate_option(CCACHE "Use ccache for compiling." "if ccache is found." AUTO)
-tristate_option(WITH_NATPMP "Enable NAT-PMP." "if libnatpmp is found." AUTO)
-tristate_option(WITH_MINIUPNPC "Enable UPnP." "if libminiupnpc is found." AUTO)
-tristate_option(WITH_ZMQ "Enable ZMQ notifications." "if libzmq is found." AUTO)
+
+option(WITH_NATPMP "Enable NAT-PMP." OFF)
+if(WITH_NATPMP)
+  find_package(NATPMP MODULE REQUIRED)
+endif()
+
+option(WITH_MINIUPNPC "Enable UPnP." OFF)
+if(WITH_MINIUPNPC)
+  find_package(MiniUPnPc MODULE REQUIRED)
+endif()
+
+option(WITH_ZMQ "Enable ZMQ notifications." OFF)
+if(WITH_ZMQ)
+  if(VCPKG_TARGET_TRIPLET)
+    find_package(ZeroMQ CONFIG REQUIRED)
+  else()
+    # The ZeroMQ project has provided config files since v4.2.2.
+    # TODO: Switch to find_package(ZeroMQ) at some point in the future.
+    include(CrossPkgConfig)
+    cross_pkg_check_modules(libzmq REQUIRED IMPORTED_TARGET libzmq>=4)
+    target_link_libraries(PkgConfig::libzmq INTERFACE
+      $<$<PLATFORM_ID:Windows>:iphlpapi;ws2_32>
+    )
+  endif()
+endif()
+
 tristate_option(WITH_USDT
   "Enable tracepoints for Userspace, Statically Defined Tracing."
   "if sys/sdt.h is found."
@@ -84,7 +107,12 @@ tristate_option(WITH_EXTERNAL_SIGNER
   AUTO
 )
 tristate_option(WITH_QRENCODE "Enable QR code support." "if libqrencode is found." AUTO)
-tristate_option(MULTIPROCESS "Build multiprocess bitcoin-node, bitcoin-wallet, and bitcoin-gui executables in addition to monolithic bitcoind and bitcoin-qt executables. Requires libmultiprocess library. Experimental." "if libmultiprocess is found." OFF)
+
+option(MULTIPROCESS "Build multiprocess bitcoin-node, bitcoin-wallet, and bitcoin-gui executables in addition to monolithic bitcoind and bitcoin-qt executables. Requires libmultiprocess library. Experimental." OFF)
+if(MULTIPROCESS)
+  find_package(Libmultiprocess CONFIG REQUIRED)
+  find_package(LibmultiprocessGen CONFIG REQUIRED)
+endif()
 
 option(BUILD_TESTS "Build test_bitcoin executable." ON)
 cmake_dependent_option(BUILD_GUI_TESTS "Build test_bitcoin-qt executable." ON "BUILD_TESTS" OFF)
diff --git a/CMakePresets.json b/CMakePresets.json
index b5bcd3238f6c5..6078f81b02bb4 100644
--- a/CMakePresets.json
+++ b/CMakePresets.json
@@ -2,6 +2,48 @@
   "version": 3,
   "cmakeMinimumRequired": {"major": 3, "minor": 21, "patch": 0},
   "configurePresets": [
+    {
+      "name": "ci-common",
+      "hidden": true,
+      "cacheVariables": {
+        "ENABLE_WALLET": "ON",
+        "WITH_SQLITE": "ON",
+        "WITH_BDB": "ON",
+        "WITH_NATPMP": "ON",
+        "WITH_MINIUPNPC": "ON",
+        "WITH_ZMQ": "ON",
+        "WERROR": "ON",
+        "CCACHE": "ON"
+      }
+    },
+    {
+      "name": "ci-linux",
+      "inherits": "ci-common",
+      "displayName": "Build for CI tests on Linux",
+      "condition": {
+        "type": "equals",
+        "lhs": "${hostSystemName}",
+        "rhs": "Linux"
+      },
+      "cacheVariables": {
+        "WITH_EXTERNAL_SIGNER": "ON",
+        "WITH_USDT": "ON"
+      }
+    },
+    {
+      "name": "ci-darwin",
+      "inherits": "ci-common",
+      "displayName": "Build for CI tests on macOS",
+      "condition": {
+        "type": "equals",
+        "lhs": "${hostSystemName}",
+        "rhs": "Darwin"
+      },
+      "cacheVariables": {
+        "WITH_GUI": "Qt5",
+        "WITH_EXTERNAL_SIGNER": "ON"
+      }
+    },
     {
       "name": "vs2022",
       "displayName": "Build using 'Visual Studio 17 2022' generator and 'x64-windows' triplet",
diff --git a/cmake/optional.cmake b/cmake/optional.cmake
index f2a0c24f484bb..b9e167a36abe4 100644
--- a/cmake/optional.cmake
+++ b/cmake/optional.cmake
@@ -50,60 +50,6 @@ if(CCACHE)
   mark_as_advanced(CCACHE_COMMAND)
 endif()
 
-if(WITH_NATPMP)
-  find_package(NATPMP MODULE)
-  if(NATPMP_FOUND)
-    set(WITH_NATPMP ON)
-  elseif(WITH_NATPMP STREQUAL "AUTO")
-    message(WARNING "libnatpmp not found, disabling.\n"
-                    "To skip libnatpmp check, use \"-DWITH_NATPMP=OFF\".\n")
-    set(WITH_NATPMP OFF)
-  else()
-    message(FATAL_ERROR "libnatpmp requested, but not found.")
-  endif()
-endif()
-
-if(WITH_MINIUPNPC)
-  find_package(MiniUPnPc MODULE)
-  if(MiniUPnPc_FOUND)
-    set(WITH_MINIUPNPC ON)
-  elseif(WITH_MINIUPNPC STREQUAL "AUTO")
-    message(WARNING "libminiupnpc not found, disabling.\n"
-                    "To skip libminiupnpc check, use \"-DWITH_MINIUPNPC=OFF\".\n")
-    set(WITH_MINIUPNPC OFF)
-  else()
-    message(FATAL_ERROR "libminiupnpc requested, but not found.")
-  endif()
-endif()
-
-if(WITH_ZMQ)
-  if(MSVC)
-    find_package(ZeroMQ CONFIG)
-  else()
-    # The ZeroMQ project has provided config files since v4.2.2.
-    # TODO: Switch to find_package(ZeroMQ) at some point in the future.
-    include(CrossPkgConfig)
-    cross_pkg_check_modules(libzmq IMPORTED_TARGET libzmq>=4)
-    if(libzmq_FOUND AND TARGET PkgConfig::libzmq)
-      target_compile_definitions(PkgConfig::libzmq INTERFACE
-        $<$<PLATFORM_ID:Windows>:ZMQ_STATIC>
-      )
-      target_link_libraries(PkgConfig::libzmq INTERFACE
-        $<$<PLATFORM_ID:Windows>:iphlpapi;ws2_32>
-      )
-    endif()
-  endif()
-  if(TARGET libzmq OR TARGET PkgConfig::libzmq)
-    set(WITH_ZMQ ON)
-  elseif(WITH_ZMQ STREQUAL "AUTO")
-    message(WARNING "libzmq not found, disabling.\n"
-                    "To skip libzmq check, use \"-DWITH_ZMQ=OFF\".\n")
-    set(WITH_ZMQ OFF)
-  else()
-    message(FATAL_ERROR "libzmq requested, but not found.")
-  endif()
-endif()
-
 if(WITH_USDT)
   find_path(SystemTap_INCLUDE_DIR
     NAMES sys/sdt.h
@@ -189,12 +135,13 @@ else()
 endif()
 
 if(WITH_GUI AND WITH_QRENCODE)
-  if(MSVC)
+  if(VCPKG_TARGET_TRIPLET)
     # TODO: vcpkg fails to build libqrencode package due to
     #       the build error in its libiconv dependency.
     #       See: https://github.com/microsoft/vcpkg/issues/36924.
   else()
-    cross_pkg_check_modules(libqrencode libqrencode IMPORTED_TARGET)
+    include(CrossPkgConfig)
+    cross_pkg_check_modules(libqrencode IMPORTED_TARGET libqrencode)
   endif()
   if(TARGET PkgConfig::libqrencode)
     set_target_properties(PkgConfig::libqrencode PROPERTIES
@@ -207,15 +154,3 @@ if(WITH_GUI AND WITH_QRENCODE)
     message(FATAL_ERROR "libqrencode requested, but not found.")
   endif()
 endif()
-
-if(MULTIPROCESS)
-  find_package(Libmultiprocess CONFIG)
-  find_package(LibmultiprocessGen CONFIG)
-  if(TARGET Libmultiprocess::multiprocess AND TARGET Libmultiprocess::mpgen)
-    set(MULTIPROCESS ON)
-  elseif(MULTIPROCESS STREQUAL "AUTO")
-    set(MULTIPROCESS OFF)
-  else()
-    message(FATAL_ERROR "\"-DMULTIPROCESS=ON\" specified, but libmultiprocess library was not found.")
-  endif()
-endif()
diff --git a/depends/toolchain.cmake.in b/depends/toolchain.cmake.in
index f5178585c1529..3ccaf8fdf0c78 100644
--- a/depends/toolchain.cmake.in
+++ b/depends/toolchain.cmake.in
@@ -122,8 +122,10 @@ if(NOT WITH_QRENCODE AND "@no_qr@" STREQUAL "1")
   set(WITH_QRENCODE OFF CACHE STRING "Enable QR code support.")
 endif()
 
-if(NOT WITH_ZMQ AND "@no_zmq@" STREQUAL "1")
-  set(WITH_ZMQ OFF CACHE STRING "Enable ZMQ notifications.")
+if("@no_zmq@")
+  set(WITH_ZMQ OFF CACHE BOOL "")
+else()
+  set(WITH_ZMQ ON CACHE BOOL "")
 endif()
 
 if(NOT ENABLE_WALLET AND "@no_wallet@" STREQUAL "1")
@@ -138,27 +140,31 @@ if(NOT WITH_SQLITE AND "@no_sqlite@" STREQUAL "1")
   set(WITH_SQLITE OFF CACHE STRING "Enable SQLite wallet support.")
 endif()
 
-if(NOT WITH_MINIUPNPC AND "@no_upnp@" STREQUAL "1")
-  set(WITH_MINIUPNPC OFF CACHE STRING "Enable UPnP.")
+if("@no_upnp@")
+  set(WITH_MINIUPNPC OFF CACHE BOOL "")
+else()
+  set(WITH_MINIUPNPC ON CACHE BOOL "")
 endif()
 
-if(NOT WITH_NATPMP AND "@no_natpmp@" STREQUAL "1")
-  set(WITH_NATPMP OFF CACHE STRING "Enable NAT-PMP.")
+if("@no_natpmp@")
+  set(WITH_NATPMP OFF CACHE BOOL "")
+else()
+  set(WITH_NATPMP ON CACHE BOOL "")
 endif()
 
 if(NOT WITH_USDT AND "@no_usdt@" STREQUAL "1")
   set(WITH_USDT OFF CACHE STRING "Enable tracepoints for Userspace, Statically Defined Tracing.")
 endif()
 
-if(NOT HARDENING AND "@no_harden@" STREQUAL "1")
-  set(HARDENING OFF CACHE STRING "Attempt to harden the resulting executables.")
+if("@no_harden@")
+  set(HARDENING OFF CACHE BOOL "")
+else()
+  set(HARDENING ON CACHE BOOL "")
 endif()
 
 if("@multiprocess@" STREQUAL "1")
-  if(NOT MULTIPROCESS)
-    set(MULTIPROCESS ON CACHE STRING "")
-  endif()
-  if(NOT LibmultiprocessGen_DIR)
-    set(LibmultiprocessGen_DIR "${CMAKE_FIND_ROOT_PATH}/native/lib/cmake/LibmultiprocessGen" CACHE PATH "")
-  endif()
+  set(MULTIPROCESS ON CACHE BOOL "")
+  set(LibmultiprocessGen_DIR "${CMAKE_FIND_ROOT_PATH}/native/lib/cmake/LibmultiprocessGen" CACHE PATH "")
+else()
+  set(MULTIPROCESS OFF CACHE BOOL "")
 endif()
diff --git a/src/CMakeLists.txt b/src/CMakeLists.txt
index 2100664b4c200..6409965a1f3c0 100644
--- a/src/CMakeLists.txt
+++ b/src/CMakeLists.txt
@@ -68,7 +68,7 @@ target_link_libraries(bitcoin_consensus
 )
 
 if(WITH_ZMQ)
-  add_subdirectory(zmq EXCLUDE_FROM_ALL)
+  add_subdirectory(zmq)
 endif()
 
 # Home for common functionality shared by different executables and libraries.
diff --git a/src/zmq/CMakeLists.txt b/src/zmq/CMakeLists.txt
index 61fdaa819ff1e..8ecb236b46003 100644
--- a/src/zmq/CMakeLists.txt
+++ b/src/zmq/CMakeLists.txt
@@ -2,7 +2,7 @@
 # Distributed under the MIT software license, see the accompanying
 # file COPYING or https://opensource.org/license/mit/.
 
-add_library(bitcoin_zmq STATIC
+add_library(bitcoin_zmq STATIC EXCLUDE_FROM_ALL
   zmqabstractnotifier.cpp
   zmqnotificationinterface.cpp
   zmqpublishnotifier.cpp
@@ -12,6 +12,8 @@ add_library(bitcoin_zmq STATIC
 target_compile_definitions(bitcoin_zmq
   INTERFACE
     ENABLE_ZMQ=1
+  PRIVATE
+    $<$<AND:$<PLATFORM_ID:Windows>,$<CXX_COMPILER_ID:GNU>>:ZMQ_STATIC>
 )
 target_link_libraries(bitcoin_zmq
   PRIVATE