diff --git a/CHANGES.rst b/CHANGES.rst
index b6523b0ab0..36f6409034 100644
--- a/CHANGES.rst
+++ b/CHANGES.rst
@@ -46,6 +46,7 @@ Changelog
 
 **Removed**
 
+- #1551 Removed dependency to plone.app.iterate
 - #1530 Removed ARImport
 - #1530 Removed stale type registrations
 - #1541 Remove add/edit options of ReferenceWidget
diff --git a/bika/lims/profiles/default/metadata.xml b/bika/lims/profiles/default/metadata.xml
index b10fbaa1b2..6f79579aaa 100644
--- a/bika/lims/profiles/default/metadata.xml
+++ b/bika/lims/profiles/default/metadata.xml
@@ -5,7 +5,6 @@
     <dependency>profile-jarn.jsi18n:default</dependency>
     <dependency>profile-Products.ATExtensions:default</dependency>
     <dependency>profile-Products.CMFEditions:CMFEditions</dependency>
-    <dependency>profile-plone.app.iterate:plone.app.iterate</dependency>
     <dependency>profile-Products.TinyMCE:TinyMCE</dependency>
     <dependency>profile-collective.js.jqueryui:default</dependency>
     <dependency>profile-Products.DataGridField:default</dependency>
diff --git a/bika/lims/upgrade/v01_03_003.py b/bika/lims/upgrade/v01_03_003.py
index 40a89160ee..b096016c4b 100644
--- a/bika/lims/upgrade/v01_03_003.py
+++ b/bika/lims/upgrade/v01_03_003.py
@@ -403,6 +403,9 @@ def upgrade(tool):
     # Add progress metadata column for Batches
     add_metadata(portal, BIKA_CATALOG, "getProgress", True)
 
+    # https://github.com/senaite/senaite.core/pull/1551
+    uninstall_plone_app_iterate(portal)
+
     # Remove stale skin layers from portal_skins
     # https://github.com/senaite/senaite.core/pull/1547
     remove_skin_layers(portal)
@@ -916,6 +919,17 @@ def remove_arimports(portal):
     logger.info("Removing AR Imports folder [DONE]")
 
 
+def uninstall_plone_app_iterate(portal):
+    """Uninstall plone.app.iterate
+    """
+    qi = api.get_tool("portal_quickinstaller")
+    profile = "plone.app.iterate"
+    if qi.isProductInstalled(profile):
+        logger.info("Uninstalling '{}' ...".format(profile))
+        qi.uninstallProducts(products=[profile])
+        logger.info("Uninstalling '{}' [DONE]".format(profile))
+
+
 def remove_skin_layers(portal):
     """Remove registered skin layers from portal_skins tool
     """