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# What is Helical ? | ||
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Helical provides a framework for and gathers state-of-the-art pre-trained bio foundation models on genomics and transcriptomics modalities. | ||
Helical provides a framework for state-of-the-art pre-trained bio foundation models on genomics and transcriptomics modalities. | ||
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Helical simplifies the entire application lifecycle when building with bio foundation models. You will be able to: | ||
- Leverage the latest bio foundation models through our easy-to-use python package | ||
- Run example notebooks on key downstream tasks from examples | ||
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We will update this repo on a bi-weekly basis with new models, benchmarks, modalities and functions - so stay tuned. | ||
We will update this repo on a regular basis with new models, benchmarks, modalities and functions - so stay tuned. | ||
Let’s build the most exciting AI-for-Bio community together! | ||
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## Installation | ||
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pip install --upgrade --force-reinstall git+https://github.com/helicalAI/helical.git | ||
``` | ||
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## Installation | ||
### RNA models: | ||
- [Geneformer](https://helical.readthedocs.io/en/latest/docs/Geneformer.html) | ||
- [scGPT](https://helical.readthedocs.io/en/latest/docs/scGPT.html) | ||
- [Universal Cell Embedding (UCE)](https://helical.readthedocs.io/en/latest/docs/UCE.html) | ||
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### DNA models: | ||
- Coming soon | ||
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## Demo & Use Cases | ||
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To run examples, be sure to have installed the Helical package (see Installation) and that it is up-to-date. | ||
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You can look directly into the example folder above, look into our [documentation](https://helical.readthedocs.io/) for step-by-step guides or directly clone the repository using: | ||
You can look directly into the example folder above and download the script of your choice, look into our [documentation](https://helical.readthedocs.io/) for step-by-step guides or directly clone the repository using: | ||
``` | ||
git clone https://github.com/helicalAI/helical.git | ||
``` | ||
Within the `example` folder, open the notebook of your choice. We recommend starting with `Geneformer-vs-UCE.ipynb` | ||
Within the `example` folder, open the notebook of your choice. We recommend starting with `Quick-Start_Tutorial.ipynb` | ||
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### RNA models: | ||
### Current Examples: | ||
- `Quick-Start_Tutorial.ipynb`: A tutorial to quickly get used to the helical package and enbironment. | ||
- `Geneformer-vs-UCE.ipynb`: Zero-Shot Reference Mapping with Geneformer & UCE and compare the outcomes. | ||
- Coming soon: new models such as scGPT, SCimilarity, scVI; benchmarking scripts; new use cases; others | ||
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### DNA models: | ||
- Coming soon: new models such as Nucleotide Transformer; others | ||
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## Stuck somewhere ? Other ideas ? | ||
We are eager to help you and interact with you. Reach out via [email protected]. | ||
You can also open github issues here. | ||
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journal = {GitHub Repository}, | ||
howpublished = {\url{https://github.com/helicalAI/helical}}, | ||
} | ||
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