THetA Version 0.6
Released April 11th, 2015
Version 0.6 introduces a new, simplified work-flow as well as support for whole-exome sequencing data. You may need to update scripts as the user interface has slightly changed. See MANUAL.txt for full details
- Added support for whole-exome sequencing data. See MANUAL.txt for instructions for whole-exome preprocessing.
- Simplified work-flow:
- THetA now takes in full segmentation files* and automatically filters and selects intervals for processing, and provides copy number estimates for all intervals
- Automatically considers both the case of one normal and one tumor sub-population, and one normal and two tumor sub-populations and selects best solution
- If you have matlab installed, THetA now automatically outputs a pdf visualization plot of the results.
- Improved runtime performance when considering multiple tumor populations for many samples.
* For whole-genome sequencing, we now recommend running BIC-seq with the default parameters (i.e. lambda=2).