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THetA Version 0.6
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@gsatas gsatas released this 11 Apr 17:28
· 140 commits to master since this release
v0.6
2daed4a
Released April 11th, 2015

Version 0.6 introduces a new, simplified work-flow as well as support for whole-exome sequencing data. You may need to update scripts as the user interface has slightly changed. See MANUAL.txt for full details

  • Added support for whole-exome sequencing data. See MANUAL.txt for instructions for whole-exome preprocessing.
  • Simplified work-flow:
    • THetA now takes in full segmentation files* and automatically filters and selects intervals for processing, and provides copy number estimates for all intervals
    • Automatically considers both the case of one normal and one tumor sub-population, and one normal and two tumor sub-populations and selects best solution
    • If you have matlab installed, THetA now automatically outputs a pdf visualization plot of the results.
  • Improved runtime performance when considering multiple tumor populations for many samples.

* For whole-genome sequencing, we now recommend running BIC-seq with the default parameters (i.e. lambda=2).

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